Chromosomal Abnormalities Leading To Miscarriage

Chromosomal Abnormalities Leading To Miscarriage

12 Oct 2022 | 2 min Read

Dr Swatee Gaggare

Author | 1 Articles

Miscarriage is a heart-breaking event in the life of a pregnant woman. It leads to physical and mental trauma or depression that is very difficult to deal with. Although it’s very difficult to identify the exact cause of miscarriage or pregnancy loss, there are several health-related factors that contribute to this condition.

More than half of the miscarriages that occur in the first 12 weeks of pregnancy may be a result of an abnormal chromosome (contain genes for determining unique traits like hair, eyes, etc.) or chromosomal defect. Miscarriage led by chromosomal abnormalities has no specific prevention but one important thing to keep in mind is that the risk of such abnormalities might increase after the age of 35.

The blighted ovum or anembryonic pregnancy is one of the defects in which the embryo fails to develop.

Molar pregnancy is another defect in which both the chromosome sets come from the father with no chromosome set from the mother. In this pregnancy, the placenta fails to grow normally leading to a failure in fetal development and miscarriage.

Partial molar pregnancy is a condition in which the 2 sets of chromosomes come from the father in addition to one set coming from the mother. In this condition, the embryo starts developing but stops within a period of time leading to miscarriage.

Trisomy 13, 16, 18, and 21 that’s characterized by an abnormal number of chromosomes. Trisomy 16 is the most commonly found abnormality in the first trimester that leads to pregnancy loss or miscarriage.

Besides the above-mentioned abnormalities monosomy (single chromosome) and other abnormalities in sex chromosomes also lead to miscarriage or stillbirths.

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